Antibiotic resistance and its consequences have now become a global crisis. The increasing resistance of bacteria combined with the misuse of drugs has led to an era of antibiotics that prove to be of no value to the affected individual. This raises the question of how to encounter Antimicrobial Resistance (AMR) and what reason lies behind the increasing resistance of these bacteria. This research has shown the causes of resistance due to motif combinations, identified through the literature review. The method employed was of two types, the manual type and by automation through a designed code. It exhibits that the decreasing number of motifs has shown higher resistance of bacteria. This is one of the approaches that have not been studied in detail. This would help in identifying a mutation pattern that could encounter the antibiotic effectiveness problem. The obtained results can be further validated through experimental procedures to deduce a concrete hypothesis. As a result, alternatives to the existing ineffective antibiotic can be designed in the future.